Ana Domenge, who later founded the Dominican convent in Perpignan, composed a written account of her spiritual intimacies with God while being held in terrible conditions in a secret prison in Barcelona. Ines of Herrera del Duque, a leather tanner's twelve-year-old daughter whose messianic prophesies captivated both children and adults, was burned at the stake along with many of her followers. Nine years after the death of Catarina de San Juan, the Inquisition banned copies of her image and biography, fearing that a cult was forming around this popular holy woman in Puebla, New Spain. Inquisitors enlisted the assistance of Marl Sanchez's daughter to prove that this Jewish converso was guilty of practicing Judaism in secret, an accusation that led to her death. In Women in the Inquisition, Mary E. Giles brings together scholars from literature, history, and religious studies to explore women's experiences under the Inquisition in both Spain and the New World.

Based on fresh archival work, the essays provide a broader perspective on the Inquisition than has previously been available. Examining the stories of fifteen women in the context of this fearful Catholic institution in both Spain and the New World, the contributors chronicle a broad range of "crimes" against the Catholic Church, including sexual transgressions, the practice of crypto-Judaism, and the writing and preaching by alumbradas that undermined Catholic orthodoxy. The accounts, representing the experiences of girls and women from different classes and geographical regions, also include the trials' vastly divergent outcomes, ranging from burning at the stake to exoneration.