“A Study in Scarlet” marks the first appearance of Sherlock Holmes and Dr. Watson, who would become the most famous detective duo in popular fiction.Watson, having returned to London after serving in the Second Anglo-Afghan War, is looking for a place to live. He is introduced to Sherlock Holmes, an eccentric man, who spends his time experimenting in a laboratory, trying to explain the significance of bloodstains as evidence in criminal trials.

Sir Arthur Conan the British writer, who created the character Sherlock Holmes was originally a physician himself. He published four novels and more than fifty short stories about Holmes and Dr. Watson. The Sherlock Holmes stories are generally considered milestones in the field of crime fiction.
The character and stories have had a profound and lasting effect on mystery writing and popular culture as a whole, with the original tales as well as thousands written by authors other than Conan Doyle being adapted into stage and radio plays, television, films, video games, and other media for over one hundred years.